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Effects of different blockers on the expression of SOCS3 in 3D models pre-treated with leptin and adiponectin. When compared with the control, the relative protein levels of SOCS3 in the compound C group, PD98059 group, okadaic acid group and <t>SB202190</t> group were 0.41, 0.94, 0.98 and 0.93 respectively. n =6. * P <0.05.
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Effects of different blockers on the expression of SOCS3 in 3D models pre-treated with leptin and adiponectin. When compared with the control, the relative protein levels of SOCS3 in the compound C group, PD98059 group, okadaic acid group and SB202190 group were 0.41, 0.94, 0.98 and 0.93 respectively. n =6. * P <0.05.

Journal: Journal of Molecular Endocrinology

Article Title: Inhibition of leptin-induced vascular extracellular matrix remodelling by adiponectin

doi: 10.1530/JME-14-0027

Figure Lengend Snippet: Effects of different blockers on the expression of SOCS3 in 3D models pre-treated with leptin and adiponectin. When compared with the control, the relative protein levels of SOCS3 in the compound C group, PD98059 group, okadaic acid group and SB202190 group were 0.41, 0.94, 0.98 and 0.93 respectively. n =6. * P <0.05.

Article Snippet: The 3D models treated with both leptin and adiponectin for 24 h were divided into five groups based on the different pre-treated compounds: control, compound C (CST, Danvers, MA, USA; 10 μM, 2 h), PD98059 (CST; 5 μM, 2 h), okadaic acid (CST; 0.5 μM, 1 h) and SB202190 (CST; 20 μM, 2 h).

Techniques: Expressing, Control